1. Respiratory infections and coinfections with similar symptoms
In recent years, respiratory infectious diseases are a popular area of public health research. Children, the elderly, malnourished, and chronically ill patients are susceptible groups. But infectious diseases of the respiratory tract are a common health threat to almost all humans.
Respiratory tract infections are diseases caused by microorganisms that invade and grow in the respiratory tract. These infections consist of upper respiratory tract infections and lower respiratory tract infections, using the larynx as a boundary.
The major pathogens that cause respiratory infections are viruses, bacteria, fungi and atypical pathogens. The viruses mainly include influenza virus, parainfluenza virus, respiratory syncytial virus (RSV), and adenovirus (ADV). Common bacteria include Haemophilus influenza, pneumococcus, and staphylococcus. Common fungi include Candida albicans and Pneumocystis jiroveci. Atypical pathogens include mycoplasma, chlamydia, etc.
The clinical symptoms of respiratory tract infections are complex with similar clinical manifestations. The same pathogen can cause multiple clinical symptoms, and the same clinical symptoms can be caused by multiple pathogens. So, it is not possible to accurately diagnose the infecting pathogen by clinical symptoms. At the same time, there are also coinfections which pose more challenges for clinical diagnosis.
2. PCR detection technology
There are various methods for the diagnosis of respiratory pathogens, described as below.
Among traditional detection, chest X-ray and routine blood testing are with low sensitivity and specificity for bacterial live virus infections.
Isolated culture is more specific but with low positive detection rate, long detection period, difficulty in collecting samples from the lower respiratory tract, high probability of contamination, and difficulty in detecting low levels of viral.
Immunology-specific antibody detection is influenced by antibody kinetics, and pathogens can only cause respiratory symptoms after they invade target cells and proliferate actively. So, the pathogen can be identified by antigen detection, but the sensitivity of this detection technique is low.
With continuous innovation, promotion, and application of molecular biology technology, PCR detection has become increasingly mature. Compared with traditional detection techniques, PCR testing technology is easier to detect respiratory disease pathogens. At the same time, it is highly accurate, timesaving, and can identify pathogenic microorganisms of coinfections.
3. Free combination of Hecin‘s PCR test reagents
Rapid detection of respiratory tract infections is important to clarify the pathogens to promote targeted treatment and reduce harm to patients.
Hecin takes the mission of protecting human respiratory health, always insists on the concept of independent research and innovation. Hecin deeply cultivates in the development of diagnostic reagents for respiratory infectious diseases.
Hecin‘s PCR test reagents are composed of single tubes, which can be flexibly combined without limitation. These reagents can prompt the simultaneous detection of multiple pathogens in one sample, solving the problem of similar clinical manifestations and often coinfections in clinical diagnosis.
Currently, Hecin has CE-certified PCR reagents that can be freely combined to detect 11 types of respiratory pathogens:
1) COVID-19
2) IAV
3) IBV
4) ADV
5) RSV
6) PIV1
7) PIV3
8) MP
9) HBoV
10) EV
11) EV71
Hecin‘s PCR test reagents of high sensitivity and simple operation, are suitable for the rapid diagnosis of diseases caused by respiratory pathogens, and are compatible with the fluorescent PCR platform.
Hecin‘s PCR test reagents are made into a freeze-dried powder reagent, which has strong stability and can be transported and stored at room temperature, eliminating the trouble of cold chain transportation and storage. Different test items are made into different colors, making it easy to distinguish. The operation is simple and convenient, and the operator does not need complicated manual packaging operations.
In the post-COVID era, the detection of respiratory pathogens is receiving more and more attention. It is very important to provide reliable pathogenic test results quickly. Hecin is committed to providing more accurate, sensitive, convenient, and fast diagnostic products to our customers.
Post time: Feb-17-2023